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We hypothesised that men with lower testosterone and higher LH levels would be more likely to experience an IHD event (either a hospital admission or death) during a follow-up period of up to 7 years.The Health in Men Study (HIMS) is a population-based study of men living in Perth, Western Australia, originally recruited for a trial of screening for abdominal aortic aneurysm (AAA) (19).

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These observations suggest a more complex role for testosterone and are consistent with the hypothesis that androgen deficiency plays a role in the pathogenesis of IHD.

Testosterone is the major circulating androgen in males and is almost entirely bound to sex hormone-binding globulin (SHBG) and albumin. The free and albumin-bound portion is generally considered most active in target tissues.

The latter actions suggest that the male hormonal milieu could be detrimental to cardiovascular health, but favourable effects of androgens are also observed.

Testosterone levels correlate inversely with arterial stiffness, intima-media thickness and aortic diameter (9, 10), predictors of cardiovascular events.

Methods Between 20, 3637 community-dwelling men aged 70–88 years underwent a clinical assessment of cardiovascular risk factors and biochemical assessment of testosterone, SHBG and LH.


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